World’s fastest growing Semantic discovery & Expert Curated Knowledgebase platform crosses 500,000 biomedical facts now

Indian Life Sciences Informatics Company, Molecular Connections announced today, that their XTractor Premium platform now has more that 503,985Expert” annotated biomedical facts from literature and is the fastest growing knowledgebase currently.

XTractor Premium platform is Fast Becoming the definitive Semantic Knowledge discovery & Expert curated Knowledgebase for Life Science Researchers. The XTractor Premium Knowledgebase in addition to more than 503,985 relationships on proteins, drugs, biological process and diseases has advanced semantic search, concept linking analytics for effective knowledge discovery and modeling.

XTractor Premium provides Precision based mining of the most relevant facts. Compared to natural language processing engines, manual annotation approach reduces false positives rate by 12-35%.

XTractor premium serves as a platform to stay current with weekly updates from PubMed. Provides “Topic Tracking” with email alerts on specific biological entities of interest via the “Watch List” feature.

The Highlights

Semantic Search: The first of its kind highly advanced search feature, where in one could query the XTractor Premium Knowledgebase using multiple ontologies. This would enable you to narrow down on your targets at ease.

Concept Linking: Our advanced query feature would enable you to make assumptions from multiple abstracts, and discover facts, which are hitherto not published.

Bibliographic search: Search based on author, organization, affiliation or country.

Save Export and Visualize: Save and export the data in user-friendly formats, also XTractor Premium is made compatible with CytoScape – so one can visualize the networks rendered using a in-house CytoScape plug-in.

Web based and onsite installation available

To know more about the advantages of the XTractor Premium and to register for a free trial account and a webex demo please visit XTractor Premium portal www.xtractor.in/premium.

About XTractor Premium Knowledgebase
XTractor knowledgebase currently contains 503,985 relationships on biomarkers, clinical trials, pathways, knockout studies, mutations, drug interactions, toxicity, pharmacokinetics, disease mechanisms. It is the Only Knowledgebase that gets updated everyday with manually annotated relationships from the latest PubMed publications and contains more than more than 1,269 Unique Drugs, 3,602 Unique Diseases, 11,407 Unique Proteins, and 3,266 Unique Biological Processes. Hence in no time one gets to access one of the largest and the most current manually annotated datasets across the world.

About Molecular Connections
Molecular Connections is a pioneering In silico Discovery Services Company. It provides high quality, cost effective curation, literature informatics solutions and annotation services as well as products. Dr. Limsoon Wong is the Chairman of Molecular Connections. Customers of Molecular Connections include leading pharmaceutical and biotechnology, drug discovery, genomics, proteomics, medical technology, equipment companies and academic institutions spanning across the globe. In addition, Molecular Connections has powerful tool development, database integration, effective data visualization capabilities, specific expertise in building knowledge bases for rapidly growing needs in, ADME Tox, clinical, drugs, chemistry and patent industries. For more information write to us at xtractorpremium@molecularconnections.com

Recent Awards
Deloitte Technology Fast 50 India Winners |Deloitte Technology Fast 500 APAC Winners |CNBC – ICICI Emerging India Awards ‘Small Enterprise of the Year’

XTractor Premium – A Platform for discovery, knowledge sharing, analysis and modelling of published biomedical facts.

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December 11, 2009 at 7:25 am Leave a comment

XTractor knowledgebase crosses 300000+ facts

XTractor is one of its kind biomedical literature knowledgebase which updates refined facts from PubMed every single day.

The XTractor Premium Knowledgebase now has more than 300000 facts  with more coverage of manually annotated drug and disease related facts published in PubMed…

The product is currently being widely used by more than 2000 researchers across the globe.

http://www.xtractor.in/premium

For a 1-month FREE Trial access: http://www.xtractor.in/trial.do

For trial access contact: http://www.xtractor.in/trial.do

October 22, 2009 at 1:06 pm Leave a comment

XTractor Premium – Semantic Search over manually indexed data

Searching through the vast repositories of biomedical literature, has been a long standing problem.  XTractor Premium comes with a highly advanced semantic search feature which enables you to mine the most relevant information in matter of seconds. In comparison to similar application which guarantee results – XTractor Premium is far more effective in addressing scientific problems. We have multiple ontologies integrated into our semantic search panel, so that your search time is reduced.

EG: You could ask questions like:
Which are the GPCR class I receptors that are involved in colon cancer
OR which of the anti asthmatic drugs are also used for treatment diabetes type 2.

The search retrieves you the most significant results- due to the fact that XTractor relies on manual annotation of data. Manual annotation enables us to reduce the false positive mapping and also enables the correct alias/synonym mapping to a large extent. So inturn better results and faster discovery.

Many biomedical search engines talk about searching through the entire Medline but results are highly erroneous as they do not handle cases such as isoform specificity of a proteins and also since they are limited to keyword based or single entity based searching it gives the end user a limited chance to view all the published findings. Many of these search engines just run their query on the top 100 or 200 abstracts for refining purposes- but XTractor Premium with its inbuilt semantic search indexes is able to quickly compute multiple relationships across entities and enables faster generation of scientific hypothesis from the evergrowing XTractor knowledgebase of more than 250000 facts.

To use Semantic search feature-  get a free access at:

http://www.xtractor.in/trial.do

October 8, 2009 at 6:19 am Leave a comment

The XTractor Premium Knowledgebase Touches 200000 mark within 1 year of its launch.

XTractor Premium – a platform for discovery, analysis and modelling of published biomedical facts.

The application also comes with –XTractor Premium Knowledgebase – The ONLY Knowledgebase that gets updated everyday with manually annotated relationships from the latest PUBMED publications.

The XTractor Premium Knowledgebase now has more than 200000 facts updated in just 1 year of its launch providing information on Disease mechanisms, Biomarkers, Drug effects and interactions, Clinical trials, Prognosis, Pathways, Knockouts, Mutations, RNAi studies, and much more…

http://www.xtractor.in/premium

For a 1-month FREE Trial access: http://www.xtractor.in/trial.do

July 28, 2009 at 5:55 am Leave a comment

XTractor Premium on Nature Methods

With the growing number of manually annotated biomedical relationships updated from latest PUBMED publications, XTractor Premium now makes its appearance in Nature Methods – a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry.

The article can be accessed at: http://www.nature.com/app_notes/nmeth/2009/090906/full/an7147.html#a1

Title: “XTractor Premium – a Knowledgebase of manually annotated biomedical relationships updated everyday from PubMed abstracts”

Author: Guru Rao
/Molecular Connections Pvt. Ltd. Bangalore IN/

The article initially addresses the main drawbacks of data mining – the organization of the quantum of published data in PUBMED, time and cost consumed in analysing these data. It brings out the utilities of the XTractor Premium, which can accurately process this vast repertoire of scientific information with a quick turn around time. It also features the advanced analytical tools that come in handy with the XTractor Premium Knowledgebase such as Semantic Search, Concept linking, Bibliographic Search and comprehensive downloadable reports for faster analysis of the biomedical data.

The case study “Tracking common gene polymorphisms across multiple Diseases using XTractor” presented in the article provides the ability of XTractor Premium to help us discover newer facts in published literature within a quick 15-20 mins analysis time.

http://www.xtractor.in/premium

For a 1-month FREE Trial access: http://www.xtractor.in/trial.do

July 21, 2009 at 9:39 am Leave a comment

XTractor Premium – Increasing coverage of proteins, diseases, drugs and processes

With the growing number of relationships, XTractor Premium Knowledgebase now contains a more comprehensive list of proteins, diseases, drugs and processes allowing the analysis of published biomedical facts on a wider range than before. We estimated the number of each of these entities annotated till date and found that XTractor Premium Knowledgebase currently covers 44% of Swiss Prot Proteins, 50 % of MesH diseases, 62% of Drugs from Drugbank and 17% of biological Processes from Gene Ontology DBs within one year of content.

entity coverage pic

http://www.xtractor.in/premium

For a 1-month FREE Trial access: http://www.xtractor.in/trial.do

July 10, 2009 at 9:21 am 1 comment

What do Lung Cancer, Ovarian Cancer, Breast Cancer and Colon Cancer have in common?

Common Proteins:
ABCB1, AKT1, AKT2, AKT3, ALDH1A1, AURKA, BCL2, BIRC5, CASP1, CASP3, CASP7, CASP8, CASP9, CCL2, CCND1, CCNE1, CD274, CD40, CD40LG, CD82, CD8A, CDH1, CDKN1A, CDKN1B, CDKN2A, CEACAM5, CTNNB1, CXCR4, DAG1, EGF, EGFR, EPHA2, ERBB2, ESR1, ESR2, FN1, FRAP1, GSTM1, HDAC1, HIF1A, HSPA5, IFNG, IGF1, IGF1R, IL1B, IL2, IL8, ITGB1, JUN, KRAS, KRT20, LEFTY2, LEP, MAP2K1, MAPK1, MAPK10, MAPK11, MAPK14, MAPK3, MAPK8, MAPK9, MKI67, MMP1, MMP13, MMP14, MMP2, MMP9, MUC1, MYC, NFKB1, NFKB2, PIK3C3, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PLAU, PLAUR, PTEN, PTGS2, PTK2, PTK2B, RB1, REL, RELA, RELB, SCGB2A2, SRC, STAT3, STK11, TERT, TGFB1, TGFB2, TGFB3, TNF, TNFRSF10B, TNFSF10, TP53, TYMS, VEGFA, VEGFB, VEGFC, VIM
Common Processes:
angiogenesis, anti-apoptosis, apoptosis, autophagy, cell adhesion, cell cycle, cell cycle arrest, cell death, cell differentiation, cell growth, cell migration, cell proliferation, DNA Methylation, drug resistance, epithelial to mesenchymal transition, gene expression, gene silencing, growth, lymphangiogenesis, metabolism, methylation, negative regulation of cell growth, negative regulation of cell proliferation, response to hypoxia, response to oxidative stress, RNA interference, signal transduction
Common Drugs:
Cetuximab, Cisplatin, Doxorubicin, Etoposide, Fluorouracil, Gefitinib, Paclitaxel
Common Diseases:
Carcinoma, Hepatocellular; Carcinoma, Lewis Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Glioblastoma; Head and Neck Neoplasms; Inflammation; Kidney Neoplasms; Leukemia; Liver Neoplasms; Melanoma; Neoplasm Metastasis; Neuroectodermal Tumors; Osteosarcoma; Pancreatic Neoplasms; Prostatic Neoplasms; Skin Neoplasms; Stomach Neoplasms; Thyroid Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms
Try XTractor Premium Semantic Search to know more: www.xtractor.in/premium
Mail us at xtractorpremium@molecularconnections.com

July 3, 2009 at 6:59 am Leave a comment

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